Cleansing from Cyberspace the Persistent Perfidy of Fraudulent Researcher Dr Timothy Kuklo

Dr. Timothy R. Kuklo is an associate professor of orthopaedic medicine at the Washington University of St Louis School of Medicine. He has taken a leave of absence from his position pending a final determination whether he should be fired, forced to resign or allowed to return to his duties. As I began to explore the accomplishments of the four physicians, “A. T. Groth,”  “R. C. Anderson,”  “H. M. Frisch” and “R. B. Islinger,” whose names appeared as forgeries on Colonel Timothy Kuklo’s specious article: “Recombinant human bone morphogenetic protein-2 for grade III open segmental tibial fractures from combat injuries in Iraq,” it is very disturbing to learn of the visiblity of this article.

But how? How does one purge this article? Males like myself also clean so excuse any gender bias.

The article invented data that claimed that Infuse was acutely effective in lower-limb tibia restoration at a rate of 92% with only a 3.2% infection rate. The article was confirmed to be falsified  and was “retracted” by the Journal of Bone and Spine Surgery in March 2009. The article had been published in the peer-review journal in August 2008.  Despite The Journal of Bone and Spine Surgery’s ex cathedra proclamation that the apparent Medronic Inc. pay-for-fake-medical-research was “formally withdrawn from the scientific literature,” such is not the case electronically.

Tens of millions of Internet users seek medical guidance on the web. It is one of the largest categories of inquiry. One can find the above article listed in many medical-resource bibliographies and search engines. I am in the process of finding information about the abused “co-authors” that Dr Kuklo faked on his manuscript. One is Dr H. M. Frisch who has a rather impressive dossier in examining orthopaedic injuries to the casualties of war. I would prefer we not wage immoral wars but we do and someone has to heal the wounded. I was impressed with Dr Frisch prolific scholarship but horrified to encounter that the colonel’s article was still attributed to Dr Frisch et al. On the website, one encounters the Kuklo forgery in full glory. It is unfair that Dr Frisch is still identified with this faked article even though it was “withdrawn” three months ago.

+ View Abstract
Helgeson MD, Potter BK, Tucker CJ, Frisch HM, and Shawen SB
Orthopedics 32(5), 2009 May – Who cited this? | PubMed ID: 19472965 | Fulltext

Recombinant human bone morphogenetic protein-2 for grade III open segmental tibial fractures from combat injuries in Iraq.
Kuklo TR, Groth AT, Anderson RC, Frisch HM, and Islinger RB
The Journal of bone and joint surgery. British volume 90(8):1068, 2008 Aug – Who cited this? | PubMed ID: 18669965

Treatment of open periarticular shoulder fractures sustained in combat-related injuries.
Mack AW, Groth AT, Frisch HM, and Doukas WC
American journal of orthopedics (Belle Mead, N.J.) 37(3):130-5, 2008 Mar

From iraq back to iraq: modern combat orthopaedic care.
Hayda RA, Mazurek MT, Powell Iv ET, Richardson MW, Frisch HM, Andersen RC, and Ficke JR

Moderators’ summary: antibiotics and infection.
Calhoun JH and Frisch HM
The Journal of the American Academy of Orthopaedic Surgeons 14(10 Suppl), 2006 Oct –

Definitive treatment of combat casualties at military medical centers.
Andersen RC, Frisch HM, Farber GL, and Hayda RA
The Journal of the American Academy of Orthopaedic Surgeons 14(10 Suppl), 2006 Oct

Galenicom, a major medical search engine, also retains the retracted article. It also is linked on a Spanish-language version which I am reproducing to demonstrate the global reach that this article “enjoys.”

Recombinant human bone morphogenetic protein-2 for grade III open segmental tibial fractures from combat injuries in Iraq.
Autores: T R Kuklo, A T Groth, R C Anderson, H M Frisch, R B Islinger
Idioma: Eng. Fecha: 2008-08-01
Revista: The Journal of bone and joint surgery. British volume (0301-620X)
Entrega: J Bone Joint Surg Br. 2008 Aug;90(8):1068-72


This is a retrospective consecutive case series of 138 Gustillo-Anderson type IIIB and IIIC segmental tibial fractures treated at Walter Reed Army Medical Center in soldiers injured in Iraq between March 2003 and March 2005. Five patients with a head injury and four who were lost to follow-up were excluded. The patients were treated definitively with either a ringed external fixator or a reamed intramedullary nail, evaluated in terms of supplementary bone grafting with either autogenous bone (group 1, 67 patients) or recombinant human bone morphogenetic protein-2 at 1.50 mg/ml applied to an absorbable collagen sponge (group 2, 62 patients). The mechanism of injury, defect size and classification, associated injuries, presence of infection, preliminary treatment/fixation, number of procedures before definitive management, time to and details of definitive management, subsequent infection, re-operation, smoking history and other complications were noted. Radiographs were assessed for union, delayed union or nonunion by an independent investigator. All the patients were male. Their mean age was 26.6 years (20 to 42) and the mean follow-up was for 15.6 months (12 to 32). Group 2 had a slightly higher profile of concomitant injuries and a slightly worse fracture classification, but these were not significant. The rate of union was 76% (51 of 67) for group 1 and 92% for group 2 (57 of 62; p = 0.015). There was also a higher rate of subsequent infection in group 1 (14.9%) compared with group 2 (3.2%; p = 0.001) and a higher rate of re-operation (28%) in group 1 (p = 0.003). There were no observed hypersensitivity reactions to the recombinant human bone morphogenetic protein-2 implant.
Copyright: The Journal of bone and joint surgery. British volume
Washington University School of Medicine, 660 S. Euclid, St. Louis, Missouri 63110, USA. kuklot
EBSCO – HTML (con suscripción)
HighWire Press – HTML (con suscripción)
Ovid Technologies, Inc. – HTML (con suscripción)
ProQuest Information and Learning – HTML (con suscripción)
Temas: Adulto, Proteinas Morfogeneticas De Hueso, Trasplantacion Osea, Estudios De Seguimiento, Fijacion De Fractura, Fracturas Expuestas, Humanos, Iraq War, 2003 -, Varón, Personal Militar, Proteinas Recombinantes, Estudios Retrospectivos, Statistics as Topic, Fracturas De La Tibia, Factor Beta Transformador De Crecimiento, Trasplantacion Autologa, Resultado Del Tratamiento, Estados Unidos

Versión para imprimirVersión para imprimir
Festuc discotecas madrid discotecas barcelona discotecas ibiza discotecas
Artículos de otras especialidades:
Medicina Intensiva, Cardiología, Neumología, Anestesiología y Reanimación, Pediatría, Cirugía Cardiovascular, Cirugía General – Ap. Digestivo, Medicina de Urgencias, Medicina del trabajo, Reumatología, Oftalmología, Traumatología

It is possible that physicians in the developing world may not have as much access to the sordid history of this article and may apply its findings to patient care. While it is likely that most physicians who practice spine and bone fracture medicine are aware that Infuse should not be used based upon Dr Kuklo’s invented claims, I am concerned that the cyberspace dissemination of this article poses a danger to unsuspecting physicians and patients.

Nota bene: To those who have defended Dr Kuklo in comments to me at the issue is not whether he has helped individual patients, which apparently and fortunately has occurred. The issue is whether a physician should practice medicine  and escape any sanctions who falsifies research, fakes the names of other authors to give the impression of a group effort, and was part of an apparent pay-to-fake-medical-research scheme. His actions were malicious and utterly at variance with the advancement of medicine. If specific allegations and information are demonstrated to be inaccurate, I will correct them. I have written more on this incident than any other blogger and have considerable knowledge of this affair. I have scrupulously attempted to combine simultaneously the factual and the normative which in my opinion is the raison d’être of reporting:

Prior Blogging on Dr Timothy Kuklo:

May 20, 2010 Wall Street Journal reporter asks question

May 20, 2010 Kuklo cited in Journal of Bone and Spine Surgery

August 20, 2009 Colonel Kuklo resigns from Wash U

July 15, 2009 A.W.O.L. Speculation

June 18, 2009 Million Dollar Baby

June 16. 2009

May 30, 2009

May 22, 2009 Dr Kuklo takes leave of absence

May 22, 2009

May 20, 2009

May 18, 2009

May 17, 2009 Dr Riew first critiqued

May 15, 2009

May 14, 2009

May 13, 2009

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